Description
Product Characteristics: CENPVorthologs were detected in a range of species, including plants, but the proline-rich region was detected only in primates, rodents, birds, and amphibians, and long proline stretches were found only in primates. Northern blot analysis showed ubiquitousCenpvexpression in mouse tissues, with highest expression in testis, followed by small intestine, brain, and kidney. Immunofluorescence microscopy of mouse fibroblasts revealed colocalization ofCenpvwith stabilized cytoplasmic microtubules. Western blot analysis of Ramos B cells detectedCENPVat an apparent molecular mass of 40 kD.
Target Information: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis